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Updated: Aug 30, 2026

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
Published on: March 17, 2020
Neurogenic Cardiac Injury
Nader M. Banki1, Jonathan G. Zaroff
1UCSF Medical Center, Division of Cardiology, 505 Parnassus Avenue, M1177, San Francisco, CA 94143, USA. zaroff@medicine.ucsf.edu
Insights
Subarachnoid hemorrhage (SAH) can cause cardiac injury, but this damage is often reversible. Prioritize treating the brain injury, as cardiac function may improve.
Area of Science:
- Neurology
- Cardiology
- Neurocritical Care
Background:
- Cardiac injury is a known complication of various brain injuries.
- Subarachnoid hemorrhage (SAH) is a frequently studied cause of neurocardiogenic injury.
- Left ventricular (LV) dysfunction and elevated troponin levels are common in SAH patients.
Purpose of the Study:
- To investigate the role of cardiac evaluation in patients with SAH.
- To determine the prognostic and therapeutic value of echocardiography in SAH.
- To assess the necessity of cardiac catheterization in SAH patients with cardiac dysfunction.
Main Methods:
- Echocardiography for prognostication and treatment guidance when LV dysfunction or elevated troponin is present.
- Clinical assessment focusing on the primary neurological condition.
- Cardiac evaluation in brain death cases to potentially expand the donor pool.
Main Results:
- Echocardiography can aid in prognostication and treatment planning for SAH.
- Cardiac catheterization is not routinely recommended for SAH patients with LV dysfunction and elevated troponin.
- Cardiac injury following SAH is generally reversible.
- Cardiac evaluation in brain death may increase organ donor availability.
Conclusions:
- Treatment of the underlying neurological condition is paramount in SAH patients, even with coexisting LV dysfunction.
- Cardiac dysfunction associated with SAH is typically reversible.
- Cardiac assessment in brain death scenarios can benefit organ donation efforts.
Abstract:
Cardiac injury may occur following many types of brain injury, although the most widely investigated form of neurocardiogenic injury is subarachnoid hemorrhage (SAH). Echocardiography may help prognosticate and aid in the treatment of SAH if left ventricular (LV) dysfunction is suspected or if troponin levels are elevated. Cardiac catheterization, however, is not routinely recommended in SAH patients with LV dysfunction and elevated troponin. The priority should be treatment of the underlying neurological condition, even in the setting of LV dysfunction. Cardiac injury that occurs following an SAH appears to be reversible. For patients that develop brain death cardiac evaluation under optimal conditions may help increase the donor pool.
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