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Published on: June 21, 2018
A whole genome screen for association with multiple sclerosis in Portuguese patients
M Santos1, J Pinto-Basto, M E Rio
1UnIGENe-IBMC, University of Porto, Portugal.
Abstract:
Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
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