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Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
Published on: September 8, 2021
In vitro activity of TD-6424 against Staphylococcus aureus
John L Pace1, Kevin Krause, Deborah Johnston
1Theravance, Inc., South San Francisco, California 94080, USA.
Antimicrobial Agents and Chemotherapy
|October 25, 2003
Abstract:
TD-6424, a rapidly bactericidal agent with multiple mechanisms of action, is more potent in vitro and more rapidly bactericidal than currently available agents against methicillin-susceptible and methicillin-resistant Staphylococcus aureus. TD-6424 produces a postantibiotic effect with a duration of 4 to 6 h against these organisms. The results suggest potential efficacy against susceptible and resistant strains of S. aureus.