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Published on: September 8, 2021
In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from anterior nares and blood
Christof von Eiff1, John F Kokai-Kun, Karsten Becker
1Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Muenster, Germany. eiffc@uni-muenster.de
Abstract:
The in vitro activity of recombinant lysostaphin was tested against a collection of well-characterized clinical Staphylococcus aureus isolates by disk diffusion (429 isolates) and minimum bactericidal concentration (10 isolates) assays. Minimum bactericidal concentrations of 0.16 microg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested.
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