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Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan
Tsi-Shu Huang1, Susan Shin-Jung Lee, Hui-Zin Tu
1Section of Microbiology and Infectious Diseases, Kaohsiung Veterans General Hospital and Department of Medical Technology, Foo-Yin Institute of Technology, Taipei, Taiwan.
Antimicrobial Agents and Chemotherapy
|October 25, 2003
Abstract:
A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.