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Updated: Jul 24, 2026

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Published on: July 7, 2015
Melatonin and jet lag: confirmatory result using a simplified protocol
1Service de Radiopharmacie et Radioanalyse, Hôpital Neuro-Cardiologique, Lyon, France.
Abstract:
This study replicates the alleviation of jet-lag with melatonin in a simplified protocol for eastward flight. At 22-n hr (n is the time-lag between the North American departure point and France), subjects took either melatonin (8 mg, n = 15), or placebo (n = 15) on the day of the return flight and for 3 consecutive days. On day 8, self-ratings significantly discriminated between melatonin and placebo for global treatment efficacy, morning fatigue, and evening sleepiness.
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