Pediatric HIV medication adherence: the views of medical providers from two primary care programs

Elizabeth Brackis-Cott1, Claude Ann Mellins, Elaine Abrams

  • 1Department of Psychiatry, Columbia University, USA. eb372@columbia.edu

Insights

Pediatric adherence to antiretroviral therapy (ART) is challenging due to complex regimens and family life issues. Healthcare providers face difficulties implementing communication strategies to improve ART adherence in children with HIV.

Area of Science:

  • Pediatric infectious diseases
  • HIV/AIDS management
  • Antiretroviral therapy adherence

Background:

  • Understanding challenges in pediatric HIV care.
  • Importance of adherence to antiretroviral therapy (ART) in children.
  • Role of healthcare providers in managing pediatric HIV.

Purpose of the Study:

  • To explore medical providers' perspectives on ART adherence in HIV-infected children.
  • To identify barriers and facilitators to adherence from a provider's viewpoint.
  • To examine the influence of the provider-patient/family relationship on adherence.

Main Methods:

  • Qualitative study involving medical providers (physicians and nurses) from primary care programs.
  • Structured questionnaires and individual interviews were used to gather data.
  • Focus on providers working with perinatally HIV-infected children.

Main Results:

  • Providers cited complex treatment regimens and limited options as major adherence challenges.
  • Family socioeconomic factors (poverty, mental health, substance use) significantly impact adherence.
  • Providers recognized communication strategies but struggled with consistent practical implementation.

Conclusions:

  • Pediatric ART adherence is intrinsically linked to the child's family life and presents long-term challenges.
  • Healthcare providers are crucial in addressing adherence issues but face systemic and familial obstacles.
  • Improved support for families and enhanced provider communication skills are essential.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...