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Widespread metastatic eccrine porocarcinoma
Rajat Goel1, Melissa J Contos, Michael L Wallace
1Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA. rgoel@hsc.vcu.edu
Journal of the American Academy of Dermatology
|October 25, 2003
Summary
Systemic spread of eccrine porocarcinoma, a rare sweat gland tumor, is uncommon. This case highlights its potential for widespread metastasis, including to the esophagus, lymph nodes, lungs, and brain.
Area of Science:
- Oncology
- Dermatopathology
Background:
- Eccrine porocarcinoma is a rare malignant neoplasm originating from the acrosyringium.
- While cutaneous metastases are known, systemic dissemination is exceptionally infrequent.
Observation:
- A 42-year-old man presented with plantar eccrine porocarcinoma.
- He subsequently developed cutaneous metastases and later presented with an esophageal mass and gastric ulcers.
Findings:
- Biopsy confirmed metastatic eccrine porocarcinoma in the esophagus and stomach.
- Metastases were also identified in lymph nodes, lungs, and brain.
- Histology revealed characteristic basaloid cells with ductal differentiation confirmed by CEA staining.
Implications:
- This case underscores the importance of considering systemic eccrine porocarcinoma metastasis in patients with unexplained masses.
- Early recognition and diagnosis are crucial for appropriate patient management.