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Topical methotrexate for lymphomatoid papulosis
Jane S Bergstrom1, Christine Jaworsky
1Department of Dermatology, University Hospitals of Cleveland, USA.
Journal of the American Academy of Dermatology
|October 25, 2003
Summary
Lymphomatoid papulosis, a skin condition with malignant-appearing cells, typically resolves on its own. Topical methotrexate effectively treated a patient with this rare lymphoproliferative disorder.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Lymphomatoid papulosis is a rare lymphoproliferative disorder.
- It presents as recurrent skin lesions that spontaneously resolve.
- Histologically, it shows a malignant-appearing infiltrate but has a benign clinical course.
Observation:
- A patient presented with lymphomatoid papulosis.
- The patient's condition was characterized by typical papules, nodules, and plaques.
- Standard treatment options have been previously described.
Findings:
- Complete resolution of lymphomatoid papulosis lesions was achieved.
- Treatment involved the topical application of methotrexate.
- This highlights a potential therapeutic approach for managing the condition.
Implications:
- Topical methotrexate may be an effective treatment for lymphomatoid papulosis.
- This finding could offer a less invasive therapeutic option.
- Further research is warranted to confirm efficacy and safety in a broader patient population.