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Updated: Aug 30, 2026
Preliminary Validation of Stereotaxic Injection Coordinates via Cryosectioning
Published on: July 19, 2024
Clinical evaluation of stereotactic brain biopsies with an MKM-mounted instrument holder
P W A Willems1, H J Noordmans, L M P Ramos
1Department of Neurosurgery, University Medical Center Utrecht, The Netherlands. p.willems@neuro.azu.nl
Object:
The aim of this study was to assess the clinical usefulness and accuracy of robot-assisted frameless stereotactic brain biopsies with a recently introduced MKM-mounted instrument holder.
Methods:
Twenty-three patients with intracranial lesions participated in this study. Depending on the size of the intracranial lesion, fiducials for image-to-patient co-ordinate transformation consisted either of bone screws or adhesive markers. Shortly after surgery, postoperative MRI-imaging was performed to demonstrate the location of the biopsy site. These images were compared with the preoperative images to assess the biopsy localisation error.
Results:
Postoperative biopsy sites could be demonstrated in six patients with bone screws and in 14 with adhesive markers. These two subgroups yielded average biopsy localisation errors of 3.3 mm (SD 1.7 mm) and 4.5 mm (SD 2.0 mm) respectively. This difference was not statistically significant. One biopsy was located in a liquefied haematoma. All others yielded pathological tissue. There were two postoperative haemorrhages, of which only one was temporarily symptomatic. There was no mortality in the first 30 days after surgery.
Conclusions:
Robot-assisted frameless point-stereotactic techniques represent an alternative to frame-based techniques for the performance of stereotactic biopsies.
