Jove
Visualize
Contact Us

Related Experiment Videos

Drug therapy in the elderly.

Rudolf E Noble1

  • 1Cathedral Hill Research Institute, San Francisco, CA 94103, USA.

Metabolism: Clinical and Experimental
|October 25, 2003
PubMed
Summary
This summary is machine-generated.

Aging alters how the body processes medications, increasing risks for older adults. Understanding these age-related changes in pharmacokinetics and pharmacodynamics is crucial for safe and effective elderly care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depression in women.

Metabolism: clinical and experimental·2005
Same author

Effects of UV-irradiation on seed germination.

The Science of the total environment·2002
Same author

Diagnosis of stress.

Metabolism: clinical and experimental·2002
Same author

Effect of environmental contaminants on nasal lysozyme secretions.

The Science of the total environment·2002
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Gerontology
  • Pharmacology
  • Clinical Medicine

Background:

  • The incidence of age-related diseases necessitates increased medication use in the elderly.
  • Older adults face a higher risk of adverse drug reactions and interactions due to polypharmacy.
  • Cognitive decline in aging can lead to medication non-adherence and management errors.

Purpose of the Study:

  • To review the impact of aging on drug responses.
  • To highlight the importance of age-related changes in pharmacokinetics and pharmacodynamics for elderly patient care.

Main Methods:

  • This is a review article, synthesizing existing literature on aging and drug response.
  • Key physiological factors influencing drug absorption, distribution, metabolism, and elimination (pharmacokinetics) are examined.

Related Experiment Videos

  • Age-related changes in drug action at the cellular level (pharmacodynamics) are analyzed.

    • Main Results:

    • Aging significantly alters pharmacokinetic processes, affecting drug concentration over time.
    • Aging impacts pharmacodynamics, leading to changes in target organ sensitivity.
    • Combined pharmacokinetic and pharmacodynamic shifts increase the risk of adverse drug events in the elderly.

    Conclusions:

    • Age-related physiological changes fundamentally influence drug efficacy and safety.
    • Healthcare providers must consider age-specific pharmacokinetic and pharmacodynamic alterations when prescribing for older adults.
    • Proactive management of these age-related drug response modifications is essential for optimizing geriatric pharmacotherapy.