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Related Experiment Videos

Recurrent inflammatory pseudotumors in children.

Joseph S Janik1, Joseph P Janik, Mark A Lovell

  • 1Department of Pediatric Surgery, The Children's Hospital, Denver, Co 80218, USA.

Journal of Pediatric Surgery
|October 25, 2003
PubMed
Summary
This summary is machine-generated.

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Pulmonary (PPT) and extrapulmonary pseudotumors (EPPT) can recur in children, especially when they spread beyond a single organ. Frequent monitoring is crucial for these benign tumors post-surgery.

Area of Science:

  • Pediatric Oncology
  • Surgical Pathology
  • Benign Neoplasms

Background:

  • Pulmonary (PPT) and extrapulmonary pseudotumors (EPPT) are rare benign tumors.
  • Complete resection generally prevents recurrence.
  • Recurrence rates and features in children are not well-documented.

Purpose of the Study:

  • To determine recurrence rates for PPT and EPPT in a pediatric population.
  • To identify features associated with pseudotumor recurrence.

Main Methods:

  • Retrospective case review of 15 children with PPT and EPPT.
  • Literature review to supplement recurrence data and identify common features of recurrent pseudotumors.

Main Results:

  • Overall pseudotumor recurrence rate was 14%.

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  • Tumors not confined to a single organ had significantly higher recurrence rates (46% for PPT, 30% for EPPT) compared to localized tumors (1.5% for PPT, 8% for EPPT).
  • Intraabdominal EPPT comprised over 75% of EPPT recurrences, which appeared between 3 months and 7 years post-resection.

    • Conclusions:

    • PPT and EPPT recur more often than previously thought.
    • Pseudotumors extending beyond a single organ have a high recurrence risk, even after seemingly adequate resection.
    • Children with extensive pseudotumors require vigilant postoperative surveillance and may benefit from adjuvant therapy at initial resection.