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08:46
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
Published on: March 7, 2017
Recurrent inflammatory pseudotumors in children
Joseph S Janik1, Joseph P Janik, Mark A Lovell
1Department of Pediatric Surgery, The Children's Hospital, Denver, Co 80218, USA.
Journal of Pediatric Surgery
|October 25, 2003
Summary
Pulmonary (PPT) and extrapulmonary pseudotumors (EPPT) can recur in children, especially when they spread beyond a single organ. Frequent monitoring is crucial for these benign tumors post-surgery.
Area of Science:
- Pediatric Oncology
- Surgical Pathology
- Benign Neoplasms
Background:
- Pulmonary (PPT) and extrapulmonary pseudotumors (EPPT) are rare benign tumors.
- Complete resection generally prevents recurrence.
- Recurrence rates and features in children are not well-documented.
Purpose of the Study:
- To determine recurrence rates for PPT and EPPT in a pediatric population.
- To identify features associated with pseudotumor recurrence.
Main Methods:
- Retrospective case review of 15 children with PPT and EPPT.
- Literature review to supplement recurrence data and identify common features of recurrent pseudotumors.
Main Results:
- Overall pseudotumor recurrence rate was 14%.
- Tumors not confined to a single organ had significantly higher recurrence rates (46% for PPT, 30% for EPPT) compared to localized tumors (1.5% for PPT, 8% for EPPT).
- Intraabdominal EPPT comprised over 75% of EPPT recurrences, which appeared between 3 months and 7 years post-resection.
Conclusions:
- PPT and EPPT recur more often than previously thought.
- Pseudotumors extending beyond a single organ have a high recurrence risk, even after seemingly adequate resection.
- Children with extensive pseudotumors require vigilant postoperative surveillance and may benefit from adjuvant therapy at initial resection.
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