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[Complement-binding and immuno-modulating properties of polyreactive immunoglobulins].

S A Bobrovnik1, K A Efetov, Iu I Petrova

  • 1Palladin Institute of Biochemistry, National Academy of Sciencis, Kyiv, Ukraine. sab@biochem.kiev.ua

Ukrains'Kyi Biokhimichnyi Zhurnal (1999 )
|October 28, 2003
PubMed
Summary
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FUNDAMENTAL DIFFERENCES BETWEEN NATURAL ANTIBODIES AND POLYREACTIVE IMMUNOGLOBULINS.

Ukrainian biochemical journal·2016

Polyreactive immunoglobulins (PRIG) bind C1q similarly to intact immunoglobulins. PRIG can enhance immune responses to low-immunogenic antigens like PPD, suggesting immuno-modulating properties.

Area of Science:

  • Immunology
  • Biochemistry

Context:

  • Polyreactive immunoglobulins (PRIG) are a subset of immunoglobulins with diverse binding capabilities.
  • Understanding PRIG's biological properties is crucial for their potential therapeutic applications.

Purpose:

  • To investigate the biological properties of PRIG, specifically their interaction with complement component C1q and their effect on immune responses.
  • To determine if PRIG exhibit immuno-modulating effects on the immune response to specific antigens.

Summary:

  • Mouse serum immunoglobulins treated with 4 M KSCN yielded PRIG with C1q binding capacity comparable to intact immunoglobulins.
  • Intravenous administration of PRIG with sheep red blood cells or heat-inactivated staphylococcal bacteria did not alter the immune response.
  • However, co-administration of PRIG with purified protein derivative of tuberculin (PPD) resulted in a tenfold increase in the mouse antibody response to PPD.

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Impact:

  • These findings indicate that PRIG possess immuno-modulating properties, particularly for low-immunogenic antigens.
  • This research opens avenues for exploring PRIG as potential agents in immunotherapy for diseases involving weak immune responses.