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[Fluoroquinolone susceptibility of Pseudomonas aeruginosa strains isolated from clinical materials]

Zenobia Wydmuch1, Jerzy Pacha, Małgorzata Kepa

  • 1Katedra i Zakład Mikrobiologii Wydziału Farmaceutycznego SAM w Sosnowcu.

Medycyna Doswiadczalna I Mikrobiologia
|October 28, 2003
PubMed

Insights

Pseudomonas aeruginosa showed varying fluoroquinolone sensitivity, with norfloxacin and ciprofloxacin being most effective. Hospitalized patients had significantly higher rates of resistant strains compared to outpatients.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pseudomonas aeruginosa is an opportunistic pathogen frequently causing hospital-acquired infections.
  • Fluoroquinolones are a class of antibiotics commonly used to treat P. aeruginosa infections.
  • Understanding antibiotic resistance patterns is crucial for effective treatment strategies.

Purpose of the Study:

  • To analyze the sensitivity of Pseudomonas aeruginosa strains to various fluoroquinolones.
  • To compare antibiotic resistance between strains isolated from hospitalized and outpatient populations.

Main Methods:

  • Disk diffusion method was employed to test antibiotic sensitivity.
  • National Committee for Clinical Laboratory Standards (NCCLS) guidelines were followed.
  • 120 P. aeruginosa strains were analyzed, sourced from hospitalized (76) and outpatient (44) individuals.

Main Results:

  • Norfloxacin and ciprofloxacin demonstrated the highest sensitivity rates across tested strains.
  • None of the P. aeruginosa strains were sensitive to flumequine.
  • Antibiotic resistance was significantly higher in strains from hospitalized patients (51.3%) compared to outpatients (13.6%).

Conclusions:

  • Norfloxacin and ciprofloxacin are effective against a substantial proportion of P. aeruginosa strains.
  • Fluoroquinolone resistance is a significant concern, particularly in hospitalized patients.
  • Surveillance of antibiotic resistance patterns is essential for guiding clinical practice.

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