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[Development of new therapeutic method for empyema].
Hiroyasu Yokomise1, Taku Okamoto, Masashi Gotoh
1Second Department of Surgery, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. yokomise@kms.ac.jp
Kekkaku : [Tuberculosis]
|October 28, 2003
Summary
Polylactic acid (PLA) sponge and fibroblast growth factor (FGF) can induce fibrotic tissue in postpneumonectomy dead space. This suggests a new method for reducing dead space using the body's own fibrotic materials.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Surgical Innovation
Background:
- Post-pneumonectomy patients often experience complications due to dead space.
- Effective methods for managing this dead space are crucial for patient recovery.
Purpose of the Study:
- To investigate if polylactic acid (PLA) sponge and fibroblast growth factor (FGF) can induce fibrotic tissue.
- To evaluate the potential of this method for filling post-pneumonectomy dead space.
Main Methods:
- White Japanese rabbits underwent left pneumonectomy.
- PLA sponge with FGF released from gelatin beads was implanted in the experimental group.
- A control group received no treatment.
Main Results:
- The control group showed no fibrotic material and lung herniation.
- The PLA sponge and FGF group developed dense fibrotic material within one month.
- Pathological examination confirmed PLA sponge and FGF promoted fibrotic tissue organization.
Conclusions:
- PLA sponge and FGF can successfully induce fibrotic material in post-pneumonectomy dead space.
- This approach offers a potential new therapeutic strategy for dead space reduction using autologous fibrotic materials.