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Related Experiment Videos

Resistin expression in different adipose tissue depots during rat development.

Paula Oliver1, Catalina Picó, Francisca Serra

  • 1Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain.

Molecular and Cellular Biochemistry
|October 28, 2003
PubMed
Summary

This study reveals that resistin gene expression in rat white adipose tissue (WAT) varies by location and age, with circulating resistin levels increasing with age and body fat. This suggests nutritional influences on resistin regulation.

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Area of Science:

  • Endocrinology
  • Metabolic research
  • Adipose tissue biology

Background:

  • Resistin, a hormone from adipocytes, was initially linked to insulin resistance in obesity.
  • Its precise physiological functions remain incompletely understood.
  • Understanding resistin's role requires investigating its expression patterns.

Purpose of the Study:

  • To investigate the ontogenic pattern of resistin mRNA expression in various white adipose tissue (WAT) depots and brown adipose tissue (BAT) in rats.
  • To analyze circulating resistin levels across different ages.
  • To explore potential nutritional regulation of resistin expression.

Main Methods:

  • Northern blotting was used to determine resistin mRNA levels in different adipose tissue depots (epididymal, inguinal, mesenteric, retroperitoneal WAT, and BAT).

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  • Serum resistin concentrations were measured using enzyme immunoassay.
  • Rats of various ages, from suckling to one year old, were studied.

    • Main Results:

    • Resistin mRNA expression in WAT remained relatively constant with age, with notable exceptions during early development.
    • Specific WAT depots exhibited distinct resistin expression levels, with epididymal and retroperitoneal depots showing higher levels at 2 months of age.
    • Circulating resistin levels showed a positive correlation with age and body fat content.

    Conclusions:

    • Resistin expression in rat adipose tissue is site-specific and changes during early development, potentially influenced by diet transitions.
    • Increased circulating resistin levels with age likely reflect increased body fat.
    • Further research is needed to fully elucidate resistin's function and regulation.