Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue engineering in otorhinolaryngology.

M Bücheler1, A Haisch

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, University of Bonn, Bonn, Germany. markus.buecheler@ukb.uni-bonn.de

DNA and Cell Biology
|October 28, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry.

Allergologie select·2018
Same author

[Intubating laryngeal tube suction disposable: Initial clinical experiences with a novel device for endotracheal intubation].

Der Anaesthesist·2015
Same author

[Functional and audiological results of tympanoplasty type I using pure perichondrial grafts].

HNO·2013
Same author

PGA-associated heterotopic chondrocyte cocultures: implications of nasoseptal and auricular chondrocytes in articular cartilage repair.

Journal of tissue engineering and regenerative medicine·2011
Same author

In vitro and in vivo neo-cartilage formation by heterotopic chondrocytes seeded on PGA scaffolds.

Histochemistry and cell biology·2011
Same author

[CO2-laser-assisted de-epithelialization of perforation margins of persistent tympanic membrane perforations. An alternative to conventional surgical procedures].

HNO·2009

Tissue engineering offers innovative solutions for repairing damaged tissues like cartilage, bone, and respiratory epithelium. While challenges remain in in vitro fabrication and vascularization, it holds promise for reconstructive surgery and treating conditions like xerostomia.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Tissue engineering integrates clinical, cellular, and materials research to create artificial replacement tissues.
  • Established methods exist in otorhinolaryngology, but tissue engineering offers novel repair strategies.
  • Limited autologous cartilage availability for head and neck reconstruction drives tissue engineering research.

Purpose of the Study:

  • To explore the applications of tissue engineering in head and neck surgery, focusing on cartilage, bone, and respiratory epithelium regeneration.
  • To address challenges in current tissue replacement methods and investigate new therapeutic avenues.
  • To highlight the potential of tissue engineering for treating conditions like radiogenic xerostomia.

Main Methods:

Related Experiment Videos

  • Investigating matrix-based, factor-based, and cell-based therapies for bone defect reconstruction.
  • Developing bioartificial cartilage and respiratory epithelium for reconstructive purposes.
  • Exploring cell therapy concepts for salivary gland regeneration to treat xerostomia.

Main Results:

  • In vitro generation of bioartificial cartilage is possible, but in vivo resorption remains a challenge.
  • Tissue engineering offers three distinct approaches for bone reconstruction: matrix, factor, and cell-based therapies.
  • Bioartificial respiratory epithelium shows potential for tracheal prostheses and scar prophylaxis.
  • Cell therapy concepts are being investigated for radiogenic xerostomia treatment.

Conclusions:

  • Tissue engineering provides new avenues for generating vital and functional tissue replacements.
  • Significant challenges persist, including limitations in in vitro cell expansion and nutrient/oxygen supply for complex tissues.
  • Ensuring adequate vascularization is critical for the survival of implanted engineered tissues.