Is agranulocytosis following infectious mononucleosis caused by autoimmunity?
Stéphane Auvin1, Jean-Hugues Dalle, Patrice-Serge Ganga-Zandzou
1Department of Pediatrics, Faculty of Medicine and Children's Hospital, Lille, France. stephane.auvin@free.fr
Pediatric Hematology and Oncology
|October 28, 2003
Abstract:
A patient developed agranulocytosis after Epstein-Barr infection. Bone marrow examination revealed normal myelopoiesis with reduced mature neutrophil polymorphonuclear cells. IgG-specific antineutrophil antibodies (anti-HNA-1a) were found in serum and on polymorphonuclear cells, suggesting that the agranulocytosis after infectious mononucleosis was caused by an autoimmune mechanism.
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