Baylor multipurpose circulatory support system for short- to long-term use

Area of Science:

• Biomedical Engineering
• Cardiovascular Devices
• Medical Technology

Background:

• Development of a versatile circulatory support system for both temporary and permanent use in treating end-stage heart disease.
• Concept derived from a totally implantable electromechanical, one-piece total artificial heart (TAH).

Purpose of the Study:

• To present a multipurpose circulatory support system adaptable as a total artificial heart (TAH) or ventricular assist device (VAD).
• To highlight the system's dual pneumatic (short-term) and electromechanical (long-term) actuation capabilities.
• To detail the shared components and unique features of the TAH and VAD versions.

Main Methods:

• Design and development of a compact pumping chamber with biolized gelatin, pusher-plate, Hexsyn rubber diaphragm, and bovine pericardial valves.
• Implementation of pneumatic drive for short-term use and electromechanical drive for long-term or permanent applications.
• Comparative analysis of VAD compactness against existing investigational devices.

Main Results:

• Both TAH and VAD versions achieved a 63 ml stroke volume.
• Electromechanical TAH demonstrated 1-week survival; electromechanical VAD achieved 2-week survival without anticoagulation.
• The VADs are notably compact compared to other investigational devices.

Conclusions:

• The developed multipurpose system offers a viable solution for various cardiac support needs, including post-cardiotomy, bridge to transplantation, and permanent support for end-stage heart disease.
• The system's adaptability and promising short-term survival data suggest significant potential in clinical applications.
• Further research and clinical trials are warranted to fully establish the long-term efficacy and safety of this innovative device.