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Skeletal muscle powered pumps can work under low preload. Design considerations.
T Oda1, A T Miyamoto, Y Okamoto
1Department of Cardiovascular Surgery, Kyoto University Faculty of Medicine, Japan.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1992
Summary
Dual chambered, single layered skeletal muscle pumps demonstrated superior stroke volume and work compared to single chamber, multilayered pumps. These findings highlight the potential of DCSLP designs for enhanced cardiac assistance.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Skeletal Muscle Physiology
Background:
- Skeletal muscle-powered pumps are being investigated as potential cardiac assist devices.
- Optimizing pump design is crucial for maximizing efficiency and performance.
Purpose of the Study:
- To compare the functional characteristics of dual chambered, single layered skeletal muscle powered pumps (DCSLP) and single chamber, multilayered pumps (SCMLP).
- To evaluate pump compliance, peak developed pressure, stroke volume, stroke work, and ejection fraction.
Main Methods:
- Canine latissimus dorsi muscles were used to construct both DCSLP and SCMLP configurations.
- Pumps were tested for chamber compliance and isovolumic performance metrics under controlled preload and afterload conditions.
- Statistical analysis was performed using Student's t-test.
Main Results:
- DCSLPs exhibited higher chamber compliance than SCMLPs.
- At specific preload and afterload conditions, DCSLPs generated significantly greater stroke volume and stroke work compared to SCMLPs and their left ventricular counterparts.
- SCMLPs showed slightly higher peak developed pressure, but this was only significant at a 60 mmHg preload.
Conclusions:
- The dual chambered, single layered design offers advantages in compliance and pumping efficiency for skeletal muscle powered pumps.
- DCSLPs demonstrate superior performance in stroke volume and work output, suggesting their potential for cardiac replacement or assistance applications.