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Pulmonary function in a non-pulsatile pulmonary circulation.

M Sakaki1, Y Taenaka, E Tatsumi

  • 1Department of Artificial Organs, National Cardiovascular Research Institute, Osaka, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1992
PubMed
Summary
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Mammals tolerate non-pulsatile pulmonary blood flow, maintaining stable hemodynamics and lung tissue perfusion. This study shows pulmonary function is unaffected by non-pulsatile circulation for up to 14 days.

Area of Science:

  • Cardiovascular Physiology
  • Pulmonary Circulation Dynamics

Background:

  • Mammalian systemic circulation readily adapts to non-pulsatile flow.
  • The impact of non-pulsatile pulmonary blood flow on pulmonary circulation remains less understood.

Purpose of the Study:

  • To investigate the effects of sustained non-pulsatile pulmonary blood flow on the pulmonary circulation in a chronic animal model.
  • To analyze hemodynamic parameters and pulmonary tissue blood flow distribution under non-pulsatile conditions.

Main Methods:

  • Chronic implantation of a pulsatile right ventricular assist device (RVAD) in six goats.
  • Replacement of the pulsatile RVAD with a centrifugal pump to achieve 100% non-pulsatile pulmonary blood flow.
  • Measurement of hemodynamic parameters, blood gas data, and lung tissue blood flow using colored microspheres.

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Main Results:

  • No significant changes were observed in pulmonary arterial pressure, pulmonary vascular resistance index, or blood gas data immediately after transitioning to non-pulsatile flow.
  • The ventral to dorsal tissue blood flow ratio in the right lung's lower lobe remained unchanged between pulsatile and non-pulsatile pulmonary perfusion.
  • Cardiac output was maintained within the 80-120 ml/kg/min range throughout the experiments.

Conclusions:

  • Pulmonary circulation demonstrates immediate accommodation to non-pulsatile blood flow.
  • Pulmonary function, including blood flow distribution, is not adversely affected by non-pulsatile pulmonary circulation for up to 14 days.