Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new oral testosterone undecanoate formulation.

Frank-Michael Köhn1, Wolf-Bernhard Schill

  • 1Department of Dermatology and Allergology, Technical University, Biedersteiner Strasse 29, 80802 Munich, Germany. Frank.Koehn@lrz.tu-muenchen.de

World Journal of Urology
|October 28, 2003
PubMed
Summary

A new oral testosterone undecanoate formulation improves storage stability. This bioequivalent ester effectively treats hypogonadism symptoms, enhancing bone density, mood, and muscle mass.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adenosine-A Regulator of Human Testicular Peritubular Cells.

Andrology·2026
Same author

[Sparse beard growth and high testosterone levels].

MMW Fortschritte der Medizin·2026
Same author

Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/082, May 2025).

Geburtshilfe und Frauenheilkunde·2026
Same author

[Lumps under the skin of the penis as an incidental finding - always suspected of malignancy?]

MMW Fortschritte der Medizin·2025
Same author

[Gynecomastia in males : Diagnostics and treatment].

Urologie (Heidelberg, Germany)·2025
Same author

[Congenital bilateral aplasia of the vas deferens (CBAVD) - possible risk factor for mucoviscidosis in offsprings].

MMW Fortschritte der Medizin·2025

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Testosterone undecanoate is an oral ester used for male hypogonadism.
  • Current formulations in oleic acid have inconvenient storage requirements.
  • A new formulation uses castor oil and propylene glycol laurate for improved stability.

Purpose of the Study:

  • To introduce and evaluate a new oral testosterone undecanoate formulation.
  • To confirm bioequivalence with the previous oleic acid formulation.
  • To highlight improved storage conditions and clinical applicability.

Main Methods:

  • Pharmacokinetic and pharmacodynamic studies were conducted.
  • Bioequivalence between old and new formulations was demonstrated.
  • Controlled studies assessed efficacy in treating hypogonadism symptoms.

Related Experiment Videos

Main Results:

  • The new formulation is stable at room temperature for approximately 3 years.
  • Pharmacokinetic and pharmacodynamic profiles are bioequivalent to the old formulation.
  • Testosterone undecanoate effectively improves bone mineral density, quality of life, muscle mass, libido, and mood.

Conclusions:

  • The new testosterone undecanoate formulation offers significantly improved storage stability.
  • The bioequivalence allows direct transfer of previous study results.
  • This improved formulation maintains efficacy in treating hypogonadism and its associated symptoms.