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ACE-inhibitors-induced metabolic acidosis in a child with nephrotic syndrome

Irene Bruno1, Marco Pennesi, Federico Marchetti

  • 1Clinica Pediatrica, IRCCS Burlo Garofolo, Università di Trieste, Via dell'Istria 65/1, 34100, Trieste, Italy.

Pediatric Nephrology (Berlin, Germany)
|October 28, 2003
PubMed

Insights

Angiotensin-converting enzyme (ACE) inhibitors can cause hyperchloraemic metabolic acidosis with hypoaldosteronism in children. This rare side effect was observed in a young boy with nephrotic syndrome receiving ACE inhibitors.

Area of Science:

  • Pediatric Nephrology
  • Clinical Pharmacology

Background:

  • Angiotensin-converting enzyme (ACE) inhibitors are increasingly prescribed for pediatric conditions.
  • Nephrotic syndrome is a common kidney disorder in children requiring medical management.

Observation:

  • A 4-year-old boy with nephrotic syndrome presented with new-onset metabolic disturbances.
  • The patient was undergoing treatment with ACE inhibitors for his condition.

Findings:

  • The patient developed severe hyperchloraemic metabolic acidosis.
  • Laboratory findings indicated concurrent hypoaldosteronism.
  • These adverse effects were associated with ACE inhibitor therapy.

Implications:

  • Clinicians should consider ACE inhibitor-induced metabolic acidosis and hypoaldosteronism in pediatric patients.
  • Monitoring electrolyte balance is crucial in children treated with ACE inhibitors, especially those with nephrotic syndrome.
  • This case highlights the importance of recognizing rare adverse drug reactions in pediatric populations.

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