Related Experiment Video
Updated: Aug 30, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
Expression of NKB1 on peripheral T cells in patients with rheumatoid arthritis
Y Nakiri1, H Kaneko, S Morimoto
1Juntendo University School of Medicine, Tokyo, Japan. mayuta@hkg.odn.ne.jp
Abstract:
NKB1 inhibits cytoxic activity of T lymphocytes mediated by superantigens, which is one of the contributing factors in the pathogenesis of rheumatoid arthritis (RA). In this study, we determined the expression of NKB1 on peripheral blood T cells in patients with RA. Our findings revealed that among patients with RA, NKB1(+) CD8(+ )T cells decreased significantly in comparison to controls (ratio: P < 0.05; absolute number: P < 0.005), and this decrease was not related to or influenced by HLA-Bw4 as a ligand of NKB1. This result may suggest that decreased expression of NKB1(+) CD8(+ )T cells contributes to the pathogenesis of RA mediated by the activation of CD8(+) T cells.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
The JAK-STAT Signaling Pathway
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF