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Peritoneal membrane plasmapheresis.

R Popovich1, Z He, J Moncrief

  • 1Bioengineering Program, University of Texas, Austin.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1992
PubMed
Summary
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A new peritoneal membrane plasmapheresis technique removes plasma proteins effectively. This novel method offers a potential, affordable home treatment for protein-mediated diseases.

Area of Science:

  • Nephrology
  • Biomedical Engineering

Background:

  • Plasma protein removal is crucial for managing certain diseases.
  • Conventional extracorporeal plasmapheresis is effective but invasive and costly.

Purpose of the Study:

  • To develop and evaluate a novel method for plasma protein removal using the peritoneal membrane.
  • To assess the efficacy and feasibility of peritoneal membrane plasmapheresis as an alternative treatment.

Main Methods:

  • A novel process involving intraperitoneal infusion of hypertonic and hypotonic solutions with vasoactive agents was devised.
  • Histamine phosphate (vasodilator) in hypertonic solution facilitated protein convection across the peritoneum.
  • Norepinephrine (vasoconstrictor) in hypotonic solution restored fluid balance and maintained protein removal rates.

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Main Results:

  • Peritoneal membrane plasmapheresis achieved protein removal rates comparable to conventional methods.
  • Canine studies demonstrated 30-50% total serum protein removal per day over 13 days.
  • The alternating infusion strategy prevented rapid decline in protein removal efficiency.

Conclusions:

  • Peritoneal membrane plasmapheresis is a viable technique for removing plasma proteins.
  • This method offers a potentially inexpensive, continuous, and home-based treatment option.
  • It holds promise for managing protein-mediated diseases currently treated with extracorporeal plasmapheresis.