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Updated: Aug 30, 2026

High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies
Published on: September 29, 2023
Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises
Jesus Gomeza1, Koji Ohno, Heinrich Betz
1Panum Institute, University of Copenhagen, Department of Pharmacology 18.6, 3 Blegdamsvej, 2200 Copenhagen N, Denmark.
Abstract:
The amino acid glycine (Gly) serves as a neurotransmitter at excitatory and inhibitory synapses in the mammalian central nervous system. Gly concentrations at post-synaptic neurotransmitter receptors are regulated by Na+/Cl(-)-dependent Gly transporters, which are expressed in neurons and in glial cells. Recent evidence suggests that these transporters are promising targets for the treatment of psychiatric and neurological disorders, such as schizophrenia and pain. Here, recent research on the structure, regulation and pharmacology of mammalian Gly transporters is reviewed.
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