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Related Experiment Videos

Bone marrow stimulation and left ventricular function in acute myocardial infarction.

Haruo Tomoda1, Naoto Aoki

  • 1Department of Cardiology, Tokai University Hospital, Boseidai, Isehara, Kanagawa, Japan. tomoda@is.icc.u-tokai.ac.jp

Clinical Cardiology
|October 29, 2003
PubMed
Summary

Bone marrow stimulation may enhance heart recovery after acute myocardial infarction (AMI). Patients showing signs of bone marrow stimulation had better left ventricular function six months post-discharge compared to controls.

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Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Bone marrow stem cells can migrate to the peripheral blood.
  • These cells have the potential to regenerate damaged heart tissue.

Purpose of the Study:

  • To investigate if bone marrow stimulation improves myocardial functional recovery after acute myocardial infarction (AMI).

Main Methods:

  • 104 patients with anterior wall AMI treated within 12 hours were studied.
  • 23 patients showed immature blood cells (Group 1), 38 matched patients did not (Group 2).
  • Left ventricular ejection fraction (EF) was assessed on admission and 6 months post-discharge.

Main Results:

  • No significant baseline differences between groups.

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  • Initial left ventricular ejection fraction (EF) was similar (Group 1: 33±12%, Group 2: 34±8%).
  • Six months post-discharge, EF was significantly better in Group 1 (47±12%) than Group 2 (40±10%, p=0.016).

    • Conclusions:

    • Patients with AMI exhibiting signs of bone marrow stimulation showed greater improvement in left ventricular function.
    • Bone marrow stimulation may be a beneficial factor in myocardial functional recovery post-AMI.