Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional imaging and pain: behavior, perception, and modulation.

Carlo A Porro1

  • 1Dip. Scienze e Tecnologie Biomediche, University di Udine, Italy. cporro@makek.dstb.uniud.it

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|October 29, 2003
PubMed
Summary

Brain imaging reveals how pain intensity affects blood flow in specific brain regions. These findings illuminate the complex neural networks involved in pain perception and modulation, offering insights into chronic pain conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensitivity and specificity of the action observation network to kinematics, target object, and gesture meaning.

Human brain mapping·2024
Same author

Effect of visual stimuli of pain on empathy brain network in people with and without Autism Spectrum Disorder.

The European journal of neuroscience·2018
Same author

Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism.

Social neuroscience·2018
Same author

Voluntary modulation of mental effort investment: an fMRI study.

Scientific reports·2017
Same author

Diagnosing and assessing pain in neurorehabilitation: from translational research to the clinical setting. Evidence and recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation.

European journal of physical and rehabilitation medicine·2016
Same author

Cognitive modulation of pain and predictive coding. Comment on "Facing the experience of pain: a neuropsychological perspective" by Fabbro and Crescentini.

Physics of life reviews·2014

Area of Science:

  • Neuroscience
  • Pain Research
  • Medical Imaging

Background:

  • Local metabolic and blood flow rates increase in the brain and spinal cord during pain states in animals.
  • Pain intensity correlates with hemodynamic changes in widespread human brain networks, including cortical and subcortical areas.

Purpose of the Study:

  • To investigate the spatio-temporal dynamics of brain networks involved in pain perception and modulation.
  • To identify brain activity patterns associated with hyperalgesia and chronic pain conditions.

Main Methods:

  • Review of existing literature on neuroimaging studies in animal models and healthy human volunteers.
  • Analysis of hemodynamic changes in the brain related to pain intensity and modulation.

Main Results:

Related Experiment Videos

  • Identified a widespread, bilateral brain system (parietal, insular, cingulate, frontal cortex, thalamus, amygdala, midbrain) showing pain intensity-related hemodynamic changes.
  • Observed that specific activity patterns may characterize hyperalgesic states and chronic pain.
  • Noted that brain nociceptive networks are influenced by endogenous opioids, mu-opioid agonists, anticipation of pain, and attentional/placebo effects.

Conclusions:

  • Brain imaging studies are beginning to reveal the dynamic nature of neural networks underlying pain perception.
  • Understanding these brain networks is crucial for developing targeted therapies for chronic pain and hyperalgesia.
  • Modulation of pain perception by psychological factors highlights the complex interplay between the brain and pain experience.