Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioreactor state estimation and control.

Claire Komives1, Robert S Parker

  • 1Department of Chemical and Materials Engineering, San Jose State University, 1 Washington Square, San Jose, CA 95192-0082, USA. claire.komives@sjsu.edu

Current Opinion in Biotechnology
|October 29, 2003
PubMed
Summary

Model-based control strategies are now being applied to biological processes, enhancing metabolic flux models for biochemical reactors. Hybrid models combining multiple approaches show promise for effective bioprocess control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A physiologically-based model of localized mucociliary clearance in the airways.

PloS one·2025
Same author

Investigation of the Impact of Manufacturing Methods on Protein-Based Long-Acting Injectable Formulations: A Comparative Assessment for Microfluidics vs. Conventional Methods.

Pharmaceutics·2024
Same author

Nasal epithelial cell culture fluorescence recovery after photobleaching predicts cystic fibrosis therapeutic response.

ERJ open research·2023
Same author

Identification of Clinical Phenotypes in Septic Patients Presenting With Hypotension or Elevated Lactate.

Frontiers in medicine·2022
Same author

Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation.

The American journal of clinical nutrition·2022
Same author

Coupled Model of Blood Volume and Activated Clotting Factor Concentration during Childbirth.

IFAC-PapersOnLine·2021

Area of Science:

  • Biotechnology
  • Biochemical Engineering
  • Process Control

Background:

  • Advanced control methods are standard in chemical processing.
  • Model-based strategies are emerging in biological process applications.
  • Metabolic flux models are being enhanced for dynamic behavior in biochemical reactors.

Purpose of the Study:

  • To review the application of advanced control methods in biological processes.
  • To highlight the use of enhanced metabolic flux models.
  • To evaluate the performance of hybrid models in bioprocess control.

Main Methods:

  • Enhancement of metabolic flux models.
  • Implementation of model-based control strategies.
  • Development and testing of hybrid models.

Related Experiment Videos

Main Results:

  • Model-based strategies show recent advancements in biological processes.
  • Enhanced metabolic flux models accurately describe dynamic behavior.
  • Hybrid models demonstrate strong performance in bioprocess control.

Conclusions:

  • Model-based strategies are effective for bioprocess control.
  • Hybrid modeling approaches offer significant advantages for bioprocess applications.
  • Further development in this area can optimize bioprocess performance.