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Updated: Aug 30, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
A patient with epilepsia partialis continua with anti-glutamate receptor epsilon 2 antibodies
Akira Kumakura1, Tomoko Miyajima, Tatsuya Fujii
1Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan.
Abstract:
This report concerns a 6-year-old female with epilepsia partialis continua. Autoantibodies against amino- and carboxyl-terminal regions of the N-methyl-D-aspartate receptor subunit glutamate receptor epsilon 2 were detected in the serum and cerebrospinal fluid. The anti-glutamate receptor epsilon 2 subunit antibodies have been demonstrated in the serum and cerebrospinal fluid in some patients with chronic progressive epilepsia partialis continua of childhood and those with Rasmussen's encephalitis. The patient, however, did not develop any neurologic deterioration or intractable seizures. Therefore, anti-glutamate receptor epsilon 2 subunit antibodies are not specific for chronic progressive epilepsia partialis continua of childhood and Rasmussen's encephalitis.
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