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Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Hepatic sinusoidal pseudocapillarization with aging in the non-human primate.

Victoria C Cogger¹, Alessandra Warren, Robin Fraser

¹Centre for Education and Research on Ageing and ANZAC Research Institute, University of Sydney, Concord RG Hospital, Sydney, NSW 2139, Australia. victoric@physiol.usyd.edu.au

Experimental Gerontology

|October 29, 2003

Summary

Aging causes pseudocapillarization in baboon livers, characterized by thicker endothelium and reduced fenestrae. This widespread liver aging change also involves novel changes in stellate cells, similar to findings in humans.

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Area of Science:

Gerontology
Hepatology
Comparative Pathology

Background:

Age-related changes in liver sinusoids, known as pseudocapillarization, are documented in rats and humans.
These changes have significant implications for disease susceptibility in older individuals.

Purpose of the Study:

To investigate if age-related pseudocapillarization occurs in baboon livers.
To determine if this represents a widespread aging phenomenon in primates.

Main Methods:

Comparison of liver tissue from young and old baboons using transmission and scanning electron microscopy.
Immunohistochemistry was employed to analyze cellular changes and protein expression.

Main Results:

Old baboons exhibited increased sinusoidal endothelial thickness and decreased fenestrae frequency, reducing liver porosity.
Enhanced expression of laminin and von Willebrand factor was observed in older baboons.
Novel ring-shaped cells, likely fat-engorged stellate cells, were prominent in aged baboon livers.

Conclusions:

Pseudocapillarization is a significant age-related alteration in the baboon liver.
Baboon liver aging includes a unique stellate cell change not previously reported in other species.
Hepatic pseudocapillarization is a conserved aging process across multiple species, including humans and non-human primates.