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Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene
Per G Olsson1, Hiroshi Tsujioka, Sonoko Narisawa
1Department of Medical Biosciences, Medical Genetics, Umeå University, Umeå, Sweden.
Abstract:
We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene. The 2 genes were found to be oriented in head-to-tail fashion with about a 6-kilobase (kb) distance between the 3' end of ldha and the 5' end of ldhc. The ldhc gene is composed of 43% repetitive elements compared to only 16% in the ldha gene. Despite the close physical distance of mouse ldha and ldhc, the 2 genes have a very different content of repetitive elements, and this most likely reflects different levels of selective pressure.
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