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Related Experiment Videos

Nutritional parameters in children with malignancy.

Vandana Jain1, A P Dubey, S K Gupta

  • 1Department of Pediatrics, Maulana Azad Medical College, New Delhi 110 002, India.

Indian Pediatrics
|October 29, 2003
PubMed
Summary

Malnutrition significantly impacts pediatric cancer treatment outcomes. Children with malnutrition experienced higher complication rates, therapy delays, and mortality, underscoring its critical role in survival.

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Area of Science:

  • Pediatric Oncology
  • Clinical Nutrition
  • Hematology

Background:

  • Nutritional status is crucial for cancer patients.
  • Malnutrition is prevalent in children with newly diagnosed malignancy.
  • Assessing nutritional markers can predict treatment response and survival.

Purpose of the Study:

  • To evaluate the nutritional status of children with newly diagnosed malignancy.
  • To assess the relationship between nutritional status and treatment response, complications, and survival.
  • To identify key nutritional parameters influencing pediatric cancer outcomes.

Main Methods:

  • Anthropometric, hematological, and biochemical parameters were assessed in 44 children before therapy.
  • Nutritional status was categorized using weight-for-age criteria.
  • Treatment response, complications, and survival were monitored during follow-up.

Main Results:

  • Malnutrition was observed in 56.8% of children.
  • Low hemoglobin (82%), low total proteins (25%), low serum albumin (20.5%), low transferrin (27.3%), and low serum iron (16.3%) were common.
  • Malnourished children had significantly lower remission rates (38.1% vs. 69.5%), more therapy delays (38.1% vs. 8.7%), higher mortality (61.9% vs. 30.5%), and increased complications like febrile neutropenia and bleeding.
  • Low serum iron (<60 ug/dL) was linked to a higher incidence of infection (42.8% vs. 8%).

Conclusions:

  • Nutritional status is a critical determinant in pediatric cancer.
  • Malnutrition adversely affects treatment planning, complication rates, therapy response, and survival in children with malignancy.
  • Early nutritional assessment and intervention are vital for improving outcomes in pediatric cancer patients.

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