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[Sialorrhea in patients with Parkinson. A six year prospective study]
1Clínica de Trastornos del Movimiento, Servicio de Neurología, Hospital Carlos Andrade Marin, Quito, Ecuador. serranom@pi.pro.ec
Introduction:
The sialorrhea has been recognised as one of the manifestations of Parkinson's disease, with a frequency of up to 80%. The evolution of patients with sialorrhea is unknown.
Patients And Methods:
We study 26 male and 17 female patients with Parkinson's disease and sialorrhea.
Results:
Evaluation at three years showed that sialorrhea had persisting in 18 of them, at six years showed that persisted in 8 patients. We found significant impairment in the sialorrhea group.
Conclusion:
If we accept the principle, that sialorrhea are levodopa-resistant disorders as non nigrostriatal symptoms, secondary to a diffuser and more extended cerebral stem degeneration, we could assume that in these patients with sialorrhea cortical-sub cortical circuits are more widely involved leading to motor and cognitive impairment and depression.