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Related Experiment Videos

NCX-4016 NicOx.

Mario Di Napoli1, Francesca Papa

  • 1Neurological Section, SMDN-Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, 41 Via Trento, I-67039-Sulmona, AQ, Italy. mariodinapoli@katamail.com

Current Opinion in Investigational Drugs (London, England : 2000)
|October 30, 2003
PubMed
Summary
This summary is machine-generated.

NCX-4016, a novel nitric oxide-aspirin conjugate, is being investigated for cardiovascular disorders and colon cancer. Clinical trials are underway to assess its efficacy in peripheral arterial disease and in individuals at risk of colon cancer.

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Area of Science:

  • Pharmacology
  • Drug Development
  • Oncology

Background:

  • NCX-4016 is a nitric oxide-aspirin conjugate NSAID.
  • Investigated by NicOx for potential therapeutic applications.

Purpose of the Study:

  • To evaluate NCX-4016 in cardiovascular disorders.
  • To assess NCX-4016 for colon cancer treatment.

Main Methods:

  • Phase II clinical trial initiated in April 2002 for symptomatic peripheral arterial disease.
  • Phase II trial initiated in March 2003 for individuals at risk of colon cancer.

Main Results:

  • Ongoing clinical investigations.
  • Further data pending from ongoing trials.

Conclusions:

  • NCX-4016 shows potential for treating cardiovascular disorders.
  • NCX-4016 is under investigation for colon cancer prevention and treatment.