Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Primary sclerosing cholangitis--diagnosis and therapy].

Lucija Virović1, Vladimir Supanc, Marko Duvnjak

  • 1Zavod za gastroenterologiju i hepatologiju Klinika za unutarnje bolesti Klinicka bolnica Sestre milosrdnice Vinogradska 29, 10000 Zagreb, Hrvatska. lucija.virović@zg.hinet.hr

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|October 30, 2003
PubMed
Summary

Primary sclerosing cholangitis (PSC) is a chronic liver disease causing bile duct inflammation and fibrosis. Early detection via blood tests and imaging is key, with ursodeoxycholic acid and liver transplant offering treatment options.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia.

World journal of gastrointestinal surgery·2022
Same author

New Drugs on the Block-Emerging Treatments for Nonalcoholic Steatohepatitis.

Journal of clinical and translational hepatology·2021
Same author

Risk Factors for Colorectal Adenoma - Acknowledging the Burden of NAFLD.

Journal of clinical and translational hepatology·2019
Same author

Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis.

Annals of clinical biochemistry·2017
Same author

CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential.

Anticancer research·2016
Same author

Hepatitis C Virus, Insulin Resistance, and Steatosis.

Journal of clinical and translational hepatology·2016

Area of Science:

  • Hepatology
  • Gastroenterology
  • Immunology

Context:

  • Primary sclerosing cholangitis (PSC) is a rare, chronic liver disease.
  • It involves inflammation, fibrosis, and bile duct obliteration, leading to biliary cirrhosis.
  • PSC frequently co-occurs with inflammatory bowel disease, particularly ulcerative colitis.

Purpose:

  • To provide a comprehensive overview of Primary Sclerosing Cholangitis (PSC).
  • To detail the pathophysiology, clinical presentation, diagnosis, and management of PSC.
  • To highlight the association between PSC and inflammatory bowel disease.

Summary:

  • PSC is characterized by progressive bile duct damage, often asymptomatic initially.
  • Diagnosis relies on characteristic cholangiographic findings like a beaded appearance.

Related Experiment Videos

  • Elevated alkaline phosphatase and gamma-glutamyl transpeptidase are common indicators, especially in ulcerative colitis patients.

    • Impact:

    • Improved understanding of PSC pathogenesis and clinical course.
    • Facilitates earlier diagnosis and intervention for PSC patients.
    • Informs management strategies, including medical therapy and liver transplantation for advanced disease.