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Related Experiment Videos

Cognitive fatigue during a test requiring sustained attention: a pilot study.

Steven R Schwid1, Carolyn M Tyler, Eileen A Scheid

  • 1Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA. Steven_schwid@urmc.rochester.edu

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 30, 2003
PubMed
Summary

Multiple sclerosis patients experience measurable cognitive fatigue, a decline in performance on sustained attention tasks like the Paced Auditory Serial Addition Test (PASAT). This objective measurement of cognitive fatigue in MS is a significant step for future research.

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Rehabilitation Medicine

Background:

  • Fatigue is a prevalent and debilitating symptom in multiple sclerosis (MS).
  • Quantifying cognitive fatigue in MS has been challenging, hindering research into its mechanisms and effective treatments.
  • Objective measures of motor fatigue exist, but analogous measures for cognitive fatigue are needed.

Purpose of the Study:

  • To objectively measure cognitive fatigue in individuals with multiple sclerosis (MS).
  • To assess cognitive fatigue as a decline in performance during sustained attention tasks.
  • To evaluate the reliability and validity of cognitive fatigue measurements.

Main Methods:

  • Twenty clinically stable MS patients and 21 healthy controls completed the Paced Auditory Serial Addition Test (PASAT) and Digit Ordering Test (DOT).

Related Experiment Videos

  • Cognitive fatigue was quantified using two pre-specified methods for each test across two sessions.
  • Reliability was assessed using intraclass correlation coefficients (ICCs), and construct validity was examined through correlations with self-reported measures.

    • Main Results:

    • MS patients showed a statistically significant decline in PASAT performance (5.3-5.8%), indicating measurable cognitive fatigue.
    • While MS patients exhibited performance decline, group comparisons with controls did not yield significant differences.
    • The Digit Ordering Test (DOT) did not demonstrate fatigue, and test-retest reliability for fatigue measures was poor.

    Conclusions:

    • Objective, measurable cognitive fatigue exists in multiple sclerosis patients during the PASAT.
    • The PASAT shows potential as a tool for assessing cognitive fatigue in MS.
    • Further research is needed to refine measures and understand the nuances of cognitive fatigue in MS.