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Related Experiment Videos

Principles of therapeutics.

T R Miller1

  • 1Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville.

The Veterinary Clinics of North America. Equine Practice
|December 1, 1992
PubMed
Summary

Topical drug delivery for anterior segment eye diseases offers short-term benefits. Alternative methods like drug-delivery devices or injections are needed for sustained therapeutic drug levels.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Topical drug administration is standard for anterior segment eye diseases.
  • Achieving prolonged therapeutic drug levels with topical treatments is challenging.
  • Frequent administration or continuous perfusion is often necessary.

Purpose of the Study:

  • To review drug delivery methods for anterior segment eye diseases.
  • To discuss alternatives to frequent topical drug administration.
  • To highlight optimal routes for specific drug properties and conditions.

Main Methods:

  • Review of existing literature on ophthalmic drug delivery.
  • Analysis of different administration routes: topical, subconjunctival, retrobulbar, systemic, and intraocular.
  • Evaluation of drug properties influencing delivery, such as solubility and corneal penetration.

Main Results:

  • Drug-delivery devices (collagen shields, contact lenses) and subconjunctival injections can enhance topical therapy.
  • Subconjunctival injections are suitable for poorly soluble drugs with low corneal penetration.
  • Systemic administration is effective for anti-inflammatory therapy but struggles with ocular antibiotic levels due to the blood-ocular barrier.

Conclusions:

  • Augmenting topical therapy with devices or injections is crucial when frequent administration is impractical.
  • Route selection depends on drug characteristics and therapeutic goals.
  • Intraocular injections are reserved for severe cases requiring direct ocular drug access.

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