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Updated: Aug 30, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Right heart assist for beating heart coronary artery bypass grafting
P Hughes1, J M Hasenkam, I K Severinsen
1Department of Cardiothoracic and Vascular Surgery, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark. phughes@rh.dk
Insights
A right-sided circulatory assist device (RHA) effectively maintains hemodynamic stability during off-pump coronary artery bypass (OPCAB) surgery. This approach, RHA-OPCAB, offers a safe alternative to conventional coronary artery bypass grafting (cCABG), reducing complications.
Area of Science:
- Cardiovascular Surgery
- Medical Devices
Background:
- Conventional coronary artery bypass surgery (cCABG) carries risks due to cardiopulmonary bypass.
- Off-pump coronary artery bypass (OPCAB) is emerging but can cause hemodynamic instability.
- Right ventricular kinking during OPCAB can compromise patient stability.
Purpose of the Study:
- To evaluate the efficacy of a right-sided circulatory assist device (RHA) in maintaining hemodynamic stability during OPCAB.
- To compare RHA-OPCAB with cCABG in terms of patient outcomes.
Main Methods:
- A prospective study involving 50 patients undergoing RHA-OPCAB and 50 patients in a cCABG control group.
- RHA was implemented before marginal artery access in the RHA-OPCAB group.
Main Results:
- 98% of RHA-OPCAB patients achieved stable hemodynamics.
- RHA-OPCAB patients showed significantly less postoperative bleeding (P<0.001).
- Shorter ventilation times (P=0.001) and lower creatine kinase (CK) levels (P<0.001) were observed in the RHA-OPCAB group.
Conclusions:
- RHA-OPCAB is a viable and safe alternative to cCABG.
- The RHA-OPCAB procedure may lead to reduced postoperative bleeding, myocardial damage, and ventilation duration.
Objective:
Cardiopulmonary bypass used in conventional coronary artery bypass surgery (cCABG) entails a risk of complications. Consequently, the trend is moving towards off-pump coronary artery bypass (OPCAB). This procedure, however, may lead to haemodynamic instability due to kinking of the right ventricle when the posterior aspect of the heart is exposed. The aim of the study was to establish if a right-sided circulatory assist device (RHA) was able to maintain haemodynamic stability during OPCAB procedures.
Method:
In a prospective study 50 RHA-OPCAB patients and a control group of 50 cCABG patients were examined. Before accessing the marginal arteries, an RHA was established in the RHA-OPCAB patients.
Results:
A stable haemodynamic condition was achieved for 98% of the RHA-OPCAB patients. The study group had less postoperative chest drain bleeding (P<0.001), shorter ventilation time (P=0.001), and lower blood levels of creatine kinase (CK) and brain CK (P<0.001) compared to the control group.
Conclusion:
The results indicate that RHA-OPCAB is a realistic alternative to cCABG. The procedure can be safely performed most likely resulting in reduced postoperative bleeding, myocardial damage, and ventilation time.
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