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Published on: May 12, 2022
Diagnosis and treatment of malaria in children
William Stauffer1, Philip R Fischer
1Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, St. Paul, MN, USA.
Insights
Malaria diagnosis in children requires clinical suspicion, especially for those returning from tropical areas. Prompt diagnosis and treatment are crucial for preventing severe complications like cerebral malaria.
Area of Science:
- Pediatrics
- Infectious Diseases
- Tropical Medicine
Background:
- Malaria poses a significant health risk to children immigrating to or returning from tropical regions to industrialized countries.
- Clinical suspicion is paramount for the initial diagnosis of malaria in pediatric populations.
Purpose of the Study:
- To outline the diagnostic approaches for malaria in children.
- To detail the clinical presentations and management strategies for pediatric malaria.
Main Methods:
- Review of clinical presentations in nonimmune and partially immune children.
- Emphasis on diagnostic techniques including thick and thin blood smears.
- Discussion of supportive and intensive care measures for complicated cases.
Main Results:
- Malaria in nonimmune children often presents with high fever, chills, and headache.
- Partially immune children may exhibit subtler symptoms, including anemia and hepatosplenomegaly.
- Cerebral malaria can manifest as altered sensorium and seizures, requiring intensive care.
Conclusions:
- Accurate diagnosis of pediatric malaria relies on clinical suspicion and appropriate blood smear analysis.
- Effective management involves supportive care, intensive care for severe cases, and timely administration of antimalarial medications.
Abstract:
Malaria continues to be a problem for children returning or immigrating to industrialized countries from tropical regions. Proper diagnosis begins with clinical suspicion. In nonimmune children, malaria typically presents with high fever that might be accompanied by chills and headache. Symptoms and signs may be more subtle in partially immune children, and anemia and hepatosplenomegaly may also be present. Children may present with respiratory distress and/or rapidly progressing cerebral malaria that manifests as altered sensorium and, sometimes, seizures. Thick blood smears help to determine when infection is present, but a single smear without parasites is not sufficient to rule out malaria. Thin blood smears aid in identifying the species of parasite. Treatment must include careful supportive care, and intensive care measures should be available for treating children with complicated Plasmodium falciparum malaria. Medical regimens can include mefloquine, atovaquone-proguanil, sulfadoxine-pyrimethamine, quinine or quinidine, clindamycin, doxycycline, chloroquine, and primaquine.
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