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Interventions for nausea and vomiting in early pregnancy
1Division of Primary Health Care, University of Bristol, Cotham House, Cotham Hill, Bristol, UK, BS6 6JL. david.jewell@bristol.ac.uk
The Cochrane Database of Systematic Reviews
|October 30, 2003
Summary
Anti-emetic medications effectively reduce nausea in early pregnancy. While vitamin B6 may help with nausea severity, evidence for other treatments like P6 acupressure and hyperemesis gravidarum therapies is limited.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Evidence-Based Medicine
Background:
- Nausea and vomiting affect a high percentage of pregnancies.
- These symptoms are common in early pregnancy.
Purpose of the Study:
- To evaluate various treatments for nausea and vomiting in early pregnancy.
- To assess the efficacy and safety of different interventions.
Main Methods:
- Systematic review of randomized controlled trials.
- Searched Cochrane databases up to December 2002.
- Independent data extraction and quality assessment by two reviewers.
Main Results:
- Twenty-eight trials were included in the review.
- Anti-emetic medications showed a significant reduction in nausea frequency.
- Pyridoxine (vitamin B6) demonstrated effectiveness in reducing nausea severity.
Conclusions:
- Anti-emetic drugs are effective for nausea in pregnancy.
- Limited data exists on fetal outcomes from randomized trials.
- No demonstrated benefit for hyperemesis gravidarum treatments; no teratogenicity concerns from observational studies.