Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pentoxifylline for neonatal sepsis.

K Haque1, P Mohan

  • 1Epsom & St Helier NHS Trust, Division of Neonatology, Department of Child Health, Queen Mary's Hospital for Children, Wrythe Lane, Carshalton, Surrey, UK, SM5 1AA.

The Cochrane Database of Systematic Reviews
|October 30, 2003
PubMed
Summary

Pentoxifylline, an anti-inflammatory drug, may reduce mortality in newborn infants with sepsis when used with antibiotics. Further large-scale trials are needed to confirm these findings and assess safety in neonatal sepsis treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Technical and clinical assessment of latest technology SiPM integrated digital PETCT scanner.

Radiography (London, England : 1995)·2023
Same author

Esophageal squamous cell cancer in Plummer-Vinson syndrome: Is lichen planus a missing link?

Journal of postgraduate medicine·2022
Same author

A 10-year Audit of Penile Prosthesis Insertion.

Irish medical journal·2021
Same author

Clinical experience with non-invasive prenatal screening for single-gene disorders.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021
Same author

Long-term outcomes of en-bloc renal transplantation from paediatric donors into adult recipients.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2018
Same author

Reply.

AJNR. American journal of neuroradiology·2015

Area of Science:

  • Neonatal Medicine
  • Pharmacology
  • Infectious Diseases

Background:

  • Neonatal sepsis mortality remains high, especially in preterm infants.
  • Antibiotic resistance necessitates novel strategies to enhance newborn host defenses.
  • Pentoxifylline, a phosphodiesterase inhibitor, modulates inflammation and is being investigated for sepsis.

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous pentoxifylline as an adjunct to antibiotics in neonates with sepsis.
  • To assess the impact of pentoxifylline on mortality and adverse events in neonatal sepsis.

Main Methods:

  • Systematic review of randomized and quasi-randomized trials comparing pentoxifylline plus antibiotics versus placebo/no intervention.
  • Searched multiple databases (CENTRAL, MEDLINE, EMBASE, CINAHL) and other sources up to March 2003.

Related Experiment Videos

  • Included trials reporting on mortality, neurological development, hospital stay, ventilation, chronic lung disease, necrotizing enterocolitis, or adverse events.

    • Main Results:

    • Two RCTs involving 107 neonates with confirmed sepsis were analyzed.
    • Pentoxifylline adjunct therapy showed a significant reduction in all-cause mortality during hospital stay (RR 0.14, NNT 6).
    • No adverse effects were reported in the included trials; other outcomes were not reported.

    Conclusions:

    • Pentoxifylline shows potential in reducing mortality in neonatal sepsis when used with antibiotics, with no observed adverse effects.
    • The current evidence is based on a small number of neonates and trials with methodological weaknesses, requiring cautious interpretation.
    • Larger, well-designed trials are recommended to confirm efficacy and explore comparisons with other anti-inflammatory adjuncts.