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Inherited vitamin K deficiency: case report and review of literature
Zerrin Orbak1, Ayse Selimoglu, Hakan Doneray
1Department of Pediatric Endocrinolgoy, Atatürk University Faculty of Medicine, Erzurum, Turkey. zerrinorbak@yahoo.com
Abstract:
Vitamin K is the cofactor for the hepatic carboxylation of glutamic acid residues in a number of proteins including the procoagulants factors II, VII, IX, and X. The role of vitamin K in normal bone function is not fully understood. Inherited deficiency of vitamin K dependent coagulation factors is a rare bleeding disorder reported only in a few patients. Here we present an 18-month old child who presented with osteopeni due to inherited vitamin K deficiency. While the patient had high bone specific alkaline phosphatase and parathyroid hormone levels and low osteocalcin and bone mineral density values, with the regular supplementation of vitamin K all the mentioned parameters returned to normal values.
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