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Related Experiment Videos

A mouse repeat sequence conserved in eukaryotic genomes.

M Di Carlo1, G Montana, D P Romancino

  • 1Institute of Developmental Biology, C.N.R., Palermo, Italy.

Journal of Submicroscopic Cytology and Pathology
|October 1, 1992
PubMed
Summary

Simple repetitive DNA sequences play a biological role. The

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Area of Science:

  • Genomics
  • Molecular Biology

Background:

  • Simple repetitive DNA sequences are abundant in eukaryotic genomes.
  • Their biological roles are not fully understood.
  • The T2 clone contains novel repetitive sequences.

Purpose of the Study:

  • To investigate the biological significance of simple repetitive DNA sequences.
  • To characterize a novel repetitive sequence, 'CAGAGAGG', found in mouse macrophages.

Main Methods:

  • cDNA library screening and sequencing.
  • Northern and Southern blot analyses.
  • In vitro differentiation assays.

Main Results:

  • The T2 clone contains 'CAGAGAGG' and 'GATA' repetitive sequences and an open reading frame.
  • 'CAGAGAGG' is transcribed into mRNA and its expression decreases during in vitro differentiation.
  • 'CAGAGAGG' is conserved across diverse eukaryotic organisms.

Conclusions:

  • The 'CAGAGAGG' sequence is a conserved, transcribed repetitive element with a potential role in cell differentiation.
  • Repetitive DNA sequences are important components of eukaryotic genomes.

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