[Postmortem detection of hemp intoxication].

Area of Science:

• Forensic Pathology
• Toxicology
• Histochemistry

Context:

• Evaluating diagnostic tools for postmortem cannabinoid intoxication (CI).
• Assessing histochemical markers in cadavers.
• Investigating changes associated with cannabinoid use in deceased individuals.

Purpose:

• To evaluate diagnostic tools for forensic medical expertise in cases of cannabinoid intoxication (CI).
• To determine the efficacy of histochemical methods for detecting cannabinoids and associated physiological changes.
• To establish the diagnostic value of specific histochemical reactions in postmortem CI cases.

Summary:

• Histochemistry, including stable blue
• B
• (SBB) staining, was employed to detect cannabinoids in lung tissues.
• Histochemical findings revealed hyperemia and capillarostasis in the mouth and stomach, and hyperemia and edema in the lungs and brain.
• A significant decrease in aldehyde dehydrogenase (AlDG) activity was observed in the adrenal glands and brain of younger individuals. The SBB reaction in bronchial and alveolar epithelia was positive in 85% of cases, indicating high diagnostic utility.

Impact:

• Provides validated histochemical techniques for diagnosing cannabinoid intoxication in forensic settings.
• Highlights specific physiological markers indicative of CI in cadavers.
• Contributes to the accuracy and reliability of postmortem toxicological examinations.