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Isochromosome 14q and leukemia with dysplastic features
Cancer Genetics and Cytogenetics
|November 1, 1992
Summary
We describe a rare case of chronic myelomonocytic leukemia with unique characteristics and an isochromosome 14q abnormality. This finding suggests isochromosome 14q may indicate leukemia with dysplastic features.
Area of Science:
- Hematology
- Cancer Genetics
- Cytogenetics
Background:
- Chronic myelomonocytic leukemia (CMMoL) is a clonal hematopoietic stem cell disorder.
- CMMoL is characterized by peripheral blood monocytosis and signs of dysplasia in one or more myeloid lineages.
Observation:
- A patient presented with CMMoL exhibiting unusual clinical and hematological features.
- The sole cytogenetic abnormality identified was an isochromosome 14q.
Findings:
- Isochromosome 14q (or trisomy 14) was identified as the sole chromosomal abnormality.
- Literature review indicates isochromosome 14q is associated with leukemias displaying dysplastic features.
Implications:
- This case expands the understanding of chromosomal abnormalities in CMMoL.
- Isochromosome 14q may serve as a potential diagnostic or prognostic marker in myeloid neoplasms with dysplasia.