Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrogenosomes, mitochondria and early eukaryotic evolution.

T Martin Embley1, Mark van der Giezen, David S Horner

  • 1Department of Zoology, The Natural History Museum, London, SW7 5BD, UK. tme@nhm.ac.uk

IUBMB Life
|October 31, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

REMIL-IBD: Region-filtered multiple instance learning for interpretable slide-level grading of inflammatory bowel disease.

Journal of pathology informatics·2026
Same author

Bacterial and fungal biomarkers in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD): trans-kingdom interactions, Blastocystis carriage, and enterotype-succinotype stratification.

Gut pathogens·2026
Same author

Screening for Alzheimer's disease in the community using an AI-driven screening platform: design of the PREDICTOM study.

The journal of prevention of Alzheimer's disease·2026
Same author

Monitoring cancer-related fatigue and quality of life in breast and prostate cancer patients after primary treatment: a study protocol for the REBECCA trials in Norway.

Clinical and experimental medicine·2026
Same author

Molecular identification of Balantioides coli in asymptomatic pigs from Norwegian farms.

Veterinary parasitology, regional studies and reports·2026
Same author

Gut enterotype- and body mass index (BMI)-dependent effects of anthocyanin supplementation on gut microbiota composition in individuals at risk for cognitive decline: a randomized placebo-controlled trial.

Gut microbes·2025
Same journal

ALKBH4 Promotes Osteogenesis via Epigenetic Regulation of BMP2-Wnt/β-Catenin Signaling in Cervical Spine OPLL.

IUBMB life·2026
Same journal

Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes.

IUBMB life·2026
Same journal

Mechanism of PCSK9-Mediated Macrophage Activation via the CAP1/NF-κB Pathway in CAWS-Induced Kawasaki Disease Vasculitis.

IUBMB life·2026
Same journal

Hormesis and the Golden Ratio: Toward a Universal Estimator of Adaptive Capacity.

IUBMB life·2026
Same journal

MicroRNAs in HPV-Associated Carcinogenesis: Potential Biomarkers in Oropharyngeal and Cervical Cancers.

IUBMB life·2026
Same journal

PGAM1 Orchestrates Cell Cycle Progression, Glycolytic Reprogramming, and Immunosuppressive Microenvironment in Triple-Negative Breast Cancer.

IUBMB life·2026
See all related articles

Hydrogenosomes, organelles producing ATP and hydrogen, likely evolved from mitochondria in early eukaryotes. These organelles and their associated enzymes are found across diverse eukaryotic lineages, suggesting a widespread mitochondrial ancestry.

Area of Science:

  • Eukaryotic evolution
  • Cell biology
  • Biochemistry

Background:

  • Hydrogenosomes are anaerobic organelles producing ATP and hydrogen, found in diverse eukaryotes.
  • Their evolutionary origin is linked to mitochondria, with key enzymes like pyruvate:ferredoxin oxidoreductase (PFO) and hydrogenase likely present early in eukaryotic evolution.

Purpose of the Study:

  • To investigate the evolutionary origins of hydrogenosomes and their associated enzymes.
  • To explore the potential for widespread mitochondrial ancestry across all eukaryotes.

Main Methods:

  • Comparative analysis of enzyme origins (PFO, hydrogenase).
  • Identification of mitochondrial-related organelles in diverse anaerobic and parasitic protozoa.

Main Results:

Related Experiment Videos

  • Evidence suggests hydrogenosomes evolved from mitochondria.
  • Pyruvate:ferredoxin oxidoreductase (PFO) and hydrogenase enzymes are found in various eukaryotic cells, not just anaerobes.
  • Mitochondrial-related organelles discovered in early-diverging protozoa.

Conclusions:

  • All eukaryotes may possess an organelle of mitochondrial ancestry.
  • The mitochondrial endosymbiosis played a crucial role in eukaryotic evolution.
  • Further research is needed to determine the essential common function driving organelle retention.