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Improved apparatus for solid-liquid multi-stage counter-current extraction.

Kayoko Tahara¹, Yoshihiro Abe, Setsuro Sugata

¹Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato, Tokyo 105-8512, Japan.

Journal of Chromatography. A

|October 31, 2003

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A new solid-liquid multi-stage counter-current extraction apparatus enables efficient continuous enantioseparation. This system successfully separated (+/-)-Troger

Area of Science:

Chemical Engineering
Separation Science
Chiral Chemistry

Background:

Solid-liquid multi-stage counter-current extraction (SLME) is crucial for separating complex mixtures.
Continuous enantioseparation of racemic compounds remains a significant challenge in pharmaceutical and chemical industries.

Purpose of the Study:

To develop and evaluate an improved apparatus for solid-liquid multi-stage counter-current extraction (SLME).
To demonstrate the apparatus's capability for continuous enantioseparation of a model racemic compound.

Main Methods:

A novel SLME apparatus with 24 extraction vessels (20 for separation, 4 for back-extraction) was designed.
The apparatus utilizes a piston-cylinder for the solid phase and a cup-cylinder for the liquid phase.
(+/-)-Troger's base and a cellulose derivative chiral separator were employed for enantioseparation.

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Main Results:

After 50 cycles (9 hours), the apparatus achieved enantioseparation of (+/-)-Troger's base.
0.1 g of the (-)-enantiomer was recovered with 85% purity from the solid phase.
1.1 g of the (+)-enantiomer was collected with 75% purity from the liquid phase.

Conclusions:

The developed SLME apparatus is effective for continuous enantioseparation.
The system demonstrates potential for scalable and efficient chiral separations.
Further optimization could enhance purity and yield for enantiomeric compounds.