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Updated: Aug 30, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Structure-function analysis and the molecular origins of anti-DNA antibodies in systemic lupus erythematosus
J Kalsi1, C T Ravirajan, A Rahman
1Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG, UK.
Abstract:
Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE or 'lupus') develop a wide variety of clinical and serological manifestations including the presence of antibodies to double-stranded DNA (dsDNA), which are often diagnostic and potentially pathogenic. In this review, we have examined the links between the structure and function of anti-dsDNA antibodies, emphasising their clinical associations. We have also reviewed studies involving animal models, the analysis of human antibody sequences and studies of, and using, computer modelling and crystal structure.
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