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Lymphocytic vasculitis associated with the anthrax vaccine: case report and review of anthrax vaccination

Antonio E Muñiz1

  • 1Department of Emergency Medicine and Pediatrics, Medical College of Virginia, 401 N. 12th Street, Richmond, VA 23298-0401, USA.

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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Bacterial Meningitis II: Pathophysiology

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